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Co-administration of Copegus and didanosine is contraindicated. Didanosine or its active metabolite (dideoxyadenosine 5′-triphosphate) concentrations are increased when didanosine is co-administered with ribavirin.which could cause or worsen clinical toxicities. Reports of fatal hepatic failure as well as peripheral neuropathy.pancreatitis.and symptomatic hyperlactatemia/lactic acidosis have been reported in clinical trials [see Contraindications (4)] .

COPEGUS should be administered with caution to patients with pre-existing cardiac disease. Patients should be assessed before commencement of therapy and should be appropriately monitored during therapy. If there is any deterioration of cardiovascular status.therapy should be stopped [see WARNINGS AND PRECAUTIONS ].

Read this Medication Guide carefully before you start taking Copegus and read the Medication Guide each time you get more Copegus. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.

In rare cases.ribavirin can cause fatal heart problems. Get emergency medical attention if you have chest pain.

Drug-diagnostic tests. Alanine aminotransferase.aspartate aminotransferase .bilirubin . increased levels.

Worried you might have HIV? Have an HIV test – it’s the only way to know for sure.

If severe adverse reactions or laboratory abnormalities develop during combination COPEGUS/PEGASYS therapy.the dose should be modified or discontinued.if appropriate.until the adverse reactions abate or decrease in severity. If intolerance persists after dose copegus online calculator.COPEGUS/PEGASYS therapy should be discontinued. Table 3 provides guidelines for dose modifications and discontinuation based on the patient’s hemoglobin concentration and cardiac status.

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if treatment with copegus is necessary, breast-feeding should be stopped.



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