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Fentanyl.nitrates.other antihypertensives.quinidine. additive hypotension.

Q. I have high blood pressure.take diltiazem ER.and feel tired a lot. Could it be from this? And it always seems that my pulse rate is low when I take my pressure with the machine. How low is too low for your pulse rate? I do work out and am in good shape but not an athlete.

A 24-month study in rats and a 21-month study in mice showed no evidence of carcinogenicity. There was also no mutagenic response in in vitro bacterial tests. No intrinsic effect on fertility was observed in rats.

In animal models.diltiazem interferes with the slow inward (depolarizing) current in excitable tissue. It causes excitation-contraction uncoupling in various myocardial tissues without changes in the configuration of the action potential. Diltiazem produces relaxation of coronary vascular smooth muscle and dilation of both large and small coronary arteries at drug levels which cause little or no negative inotropic effect. The resultant increases in coronary blood flow (epicardial and subendocardial) occur in ischemic and nonischemic models and are accompanied by dose-dependent decreases in systemic blood pressure and decreases cheap cardizem cd peripheral resistance.

The depression of cardiac contractility.conductivity.and automaticity.as well as the vascular dilation associated with anesthetics.may be potentiated by calcium channel blockers. When used concomitantly.anesthetics and calcium blockers should be titrated carefully.

Diltiazem can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

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