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Adverse effects of methylprednisolone depend on dose.duration and medrol dose pack order of administration. Short courses of methylprednisolone are usually well-tolerated with few.mild side effects. Long term.high doses of methylprednisolone may produce predictable and potentially serious side effects. Whenever possible.the lowest effective doses of methylprednisolone should be used for the shortest length of time to minimize side effects. Alternate day dosing also can help reduce side effects.

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