In more recent times, tretinoin has been combined with antibacterials, such as erythromycin, benzoyl peroxide, and clindamycin, to form topical combination treatments for acne.

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C. difficile produces toxins A and B.which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality.as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.

Hematopoietic. Transient neutropenia (leukopenia) and eosinophilia have been reported. Reports of agranulocytosis and thrombocytopenia have been made. No direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.

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Clindamycin dosage modification may not be necessary in patients with renal disease.

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benzaclin clindamycin and benzoyl peroxide topical gel should be applied twice daily, morning and evening, or as directed by a physician, to affected areas after the skin is gently washed, rinsed with warm water and patted dry.

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