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Leflunomide is an isoxazole immunomodulatory agent that inhibits dihydroorotate dehydrogenase (a mitochondrial enzyme involved in de novo pyrimidine synthesis) and has antiproliferative activity. Several in vivo and in where to buy aravaipa avocado experimental models have demonstrated an anti-inflammatory effect.
In the event of a significant overdose or toxicity.perform an accelerated drug elimination procedure to accelerate elimination [see WARNINGS AND PRECAUTIONS ].
Arthritis is often treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor’s advice.
Coadministration of ARAVA with warfarin requires close monitoring of the international normalized ratio (INR) because teriflunomide.the active metabolite of ARAVA.may decrease peak INR by approximately 25%.
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the risk of arava-associated interstitial lung disease is increased in patients with a history of interstitial lung disease.