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The following adverse reactions have been reported in clinical trials of patients treated with ondansetron.the active ingredient of ZOFRAN. A causal relationship to therapy with ZOFRAN was unclear in many cases.

Serotonin syndrome (including altered mental status.autonomic instability.and neuromuscular symptoms) has been described following the concomitant use of 5-HT 3 receptor antagonists and other serotonergic drugs.including selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs). Monitor for the emergence of serotonin syndrome. If how much zofran while pregnant occur.discontinue ZOFRAN and initiate supportive treatment [see WARNINGS AND PRECAUTIONS ].

Ondansetron may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness.fainting) that need medical attention right away.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

DRUG INTERACTIONS. Your healthcare professionals (e.g..doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start.stop or change the dosage of any medicine before checking with them first.This drug should not be used with the following medication because a very serious interaction may occur. apomorphine.If you are currently using the medication listed above.tell your how much zofran while pregnant or pharmacist before starting ondansetron.Before using this medication.tell your doctor of all nonprescription and prescription medication you may use.especially of. tramadol.Ask your doctor or pharmacist for more details.Many drugs besides ondansetron may affect the heart rhythm (QT prolongation).including dofetilide.pimozide.procainamide.amiodarone.quinidine.sotalol.macrolide antibiotics (such as erythromycin).among others. Therefore.before using ondansetron.report all medications you are currently using to your doctor or pharmacist.This document does not contain all possible interactions. Therefore.before using this product.tell how much zofran while pregnant doctor or pharmacist of all the products you use. Keep a list of all your medications with you.how much zofran while pregnant share the list with your doctor and pharmacist.

Symptoms associated with serotonin syndrome may include the following combination of signs and symptoms. mental status changes (e.g..agitation.hallucinations.delirium.and coma).autonomic instability (e.g..tachycardia.labile blood pressure.dizziness.diaphoresis.flushing.hyperthermia).neuromuscular symptoms (e.g..tremor.rigidity.myoclonus.hyperreflexia.incoordination).seizures.with or without gastrointestinal symptoms (e.g..nausea.vomiting.diarrhea). Patients how much zofran while pregnant be monitored for the emergence of serotonin syndrome.especially with concomitant use of ZOFRAN and other serotonergic drugs. If symptoms of serotonin syndrome occur.discontinue ZOFRAN and initiate supportive treatment. Patients should be informed of the increased risk of serotonin syndrome.especially if ZOFRAN is used concomitantly with other serotonergic drugs [see DRUG INTERACTIONS .OVERDOSE ].

Table 4. Most Common Adverse Reactions in Adults a for the Prevention of Postoperative Nausea and Vomiting.A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea.vomiting and in some cases.hyperemesis gravidarum.in early pregnancy) poses no risk to the developing fetus.

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we have investigated the studies showing whether zofran is safe during pregnancy, discovered the birth defects caused by zofran, and are representing mothers and families affected by the hidden risks of zofran.



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